请帮忙做个输出样式,谢谢!
Introduction Diabetic retinopathy (DR) is aserious microvascular complication of diabetes mellitus (DM) and is one of theleading causes of blindness in working-age population in the industrializedworld[1,2].Retinal neovascularization (RNV) is the most important clinical features ofproliferative DR (PDR). A number of angiogenic factors including cytokines,inflammatory cells, growth factors, etc.have been identified to play important roles in the pathogenesis of RNV[3-6]. Vascularendothelial growth factor (VEGF) is considered to be a key molecule duringpathogenesis of RNV. Serum levels of VEGF are detected to be associated withthe development of DR[7].Although anti–VEGF therapies have proven to be effective in treating DR[8,9], the treatmentsshow a transient efficacy[10].Besides, VEGF levels were not entirely relevant to the severity of DR[4]. Thus suggest thatthere would be some other substances which also play roles in the promotion ofDR rather than upregulating VEGF expression[11]. References 1 Negi A, Vernon SA. An overview of the eyein diabetes. J R Soc Med 2003;96(6):266-272 2 Tielsch JM, Sommer A, Witt K, Katz J,Royall RM. Blindness and visual impairment in an American urban population. TheBaltimore EyeSurvey. Arch Ophthalmol 1990;108(2):286-290 3 Adamis AP. Is diabetic retinopathy aninflammatory disease? Br J Ophthalmol 2002;86(4):363-365 4 Patel JI, Tombran-Tink J, Hykin PG, GregorZJ, Cree IA. Vitreous and aqueous concentrations of proangiogenic,antiangiogenic factors and other cytokines in diabetic retinopathy patientswith macular edema: implications for structural differences in macularprofiles. Exp Eye Res 2006;82(5):798-806 5 AbuEl-Asrar AM, Struyf S, Kangave D, Geboes K, Van Damme JChemokines in proliferative diabetic retinopathy and proliferativevitreoretinopathy. Eur Cytokine Netw 2006;17(3):155-165 6 Hernandez C, Segura RM, Fonollosa A,Carrasco E, Francisco G, Simo R. Interleukin-8, monocyte chemoattractantprotein-1 and IL-10 inthe vitreous fluid of patients with proliferative diabetic retinopathy. Diabet Med 2005;22(6):719-722 全部作者都要列出,谢谢!
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